Publications

  1. Roberts, D. L., J. P. Mitchell, “Measurement of Aerodynamic Particle Size Distribution of Orally Inhaled Products by Cascade Impactor:  How to Let the Product Specification Drive the Quality Requirements of the Cascade Impactor,” AAPS Pharm. Sci. Tech., DOI:10.1208/s12249-018-1276-9 (2019).
  2. Roberts, D. L., M. Svensson, K. Sandell, D. Sandell, “Experimental and Theoretical Investigation of a New Approach to In-Use Impactor Quality Specifications,” Drug Delivery to the Lung 2018, Edinburgh, UK, The Aerosol Society, December 12-14, 2018.
  3. Mitchell, J. P., C. Blatchford, R. Greguletz, D. L. Roberts, H. Versteeg, “A European Pharmaceutical Aerosol Group (EPAG)-Led Cross-Industry Assessment of Inlet Flow Rate Profiles of Compendial DPI Test Systems:  Part 1 – Experimental Data,” Drug Delivery to the Lung 2018, Edinburgh, UK, The Aerosol Society, December 12-14, 2018.
  4. Roberts, D. L., H. Versteeg, C. Blatchford, R. Greguletz, J. P. Mitchell “A European Pharmaceutical Aerosol Group (EPAG)-Led Cross-Industry Assessment of Inlet Flow Rate Profiles of Compendial DPI Test Systems:Part 2 – First-Order Impactor Model,” Drug Delivery to the Lung 2018, Edinburgh, UK, The Aerosol Society, December 12-14, 2018.
  5. Dolovich, M. B., J. P. Mitchell, D. L. Roberts, “Re: ‘Harmonizing the Nomenclature for Therapeutic Aerosol Particle Size: A Proposal,’ by Hillyer et al.,” J. Aerosol Med. Pulmon. Drug Del., 31(4), 1-3 (2018).
  6. Roberts, D. L., C. M. Shelton, “A Practical Method for Eliminating Type I and Type II Errors when Assessing the Suitability for Continued Use of a Cascade Impactor,” Inhalation, April 2018, pages 12-18.
  7. Roberts, D. L., N. Maidment, M. A. Copley, “Improved Protocol for Relating Impactor Stage Pressure Drop to the Suitability for Routine Use,” Drug Delivery to the Lung 2017, Edinburgh, UK, The Aerosol Society, December 6 to 8, 2017, pg. 94-7.
  8. Roberts, D. L., J. P. Mitchell, “Suitability of Used Impactors – Why the ‘Effective Diameter’ Criterion Needs the ‘Jet-to-Plate’ Criterion to Assure Measurement Capability in a Good Cascade Impactor Practice (CGIP) Environment,” Drug Delivery to the Lung 2017, Edinburgh, UK, The Aerosol Society, December 6 to 8, 2017, pg. 306-10
  9. Roberts, D. L., J. P. Mitchell, “Spatial Aerosol Flow Maldistribution: A Design Flaw Confounding the Proper Calibration and Data Interpretation of Stages ‘0’ and ‘1’ of the Andersen Eight-Stage Nonviable Cascade Impactor,” Aerosol Sci. Tech., 50, 1-12 (2016).
  10. Roberts, D. L., J. P. Mitchell, ““The Next Generation Impactor (NGI™) – Manufacturing Control: Part II.  Collection Cups and the Critical Jet-to-Plate Distance,” Inhalation, August 2016, pages 9-15.
  11. Roberts, D. L., J. P. Mitchell, “The Next Generation Impactor (NGI™) – Manufacturing Control: Part I. Nozzles,” Inhalation, April 2016, pages 12-19.
  12. Nichols, S. C., J. P. Mitchell, C. M. Shelton, D. L. Roberts, “Good Cascade Impactor Practice (GCIP) and Considerations for ‘In-Use’ Specifications,” AAPS Pharm. Sci. Tech., 14(1), 375-90 (March 2013).
  13. Roberts, D. L., J. P. Mitchell, “Influence of Stage Efficiency Curves on Full-Resolution Impactor Data Interpretation,” Drug Delivery to the Lung, The Aerosol Society, Edinburgh, Scotland, December 7-9, 2011, pp. 181-4.
  14. Roberts, D. L., J. P. Mitchell, “The Effect of Nonideal Cascade Impactor Stage Collection Efficiency Curves on the Interpretation of the Size of Inhaler-Generated Aerosols,” AAPS Pharm. Sci. Tech., 14 (2), 497-510 (June 2013).
  15. Roberts, D. L., “Theory of Multi-Nozzle Impactor Stages and the Interpretation of Stage Mensuration Data,” Aerosol Sci. Tech., 43, 1119-29 (2009).
  16. Marple, V. A., B. A. Olson, K. Santhanakrishnan, D. L. Roberts, J. P. Mitchell, B. L. Hudson-Curtis, “Next Generation Pharmaceutical Impactor: A New Impactor for Pharmaceutical Inhaler Testing.  Part III.  Extension of Archival Calibration to 15 L/min,” J. Aerosol Med., 17, 335-43 (2004).
  17. Marple, V. A., D. L. Roberts, F. J. Romay, N. C. Miller, K. G. Truman, M. Van Oort, B. Olsson, M. J. Holroyd, J. P. Mitchell, D. Hochrainer, “Next Generation Pharmaceutical Impactor -- Part I: Design,” J. Aerosol Med., 16, 283-99 (2003).
  18. Marple, V. A., D. L. Roberts, B. Y. H. Liu, “Efficient High-Productivity Cascade Impactors,” US Patent 6,453,758, September 24, 2002.